• Rodrigo Collado-Chagoya, Rubén Cruz-Pantoja, Javier Hernández-Romero, Cristóbal León-Oviedo, Rosa Isela Campos-Gutiérrez, Andrea Velasco-Medina, and Guillermo Velázquez-Sámano.
• Secretaría de Salud, Hospital General de México, Servicio Alergia e Inmunología Clínica, Ciudad de México, México. rodnova87@hotmail.com.
• Rev Alerg Mex. 2018 Oct 1; 65 (4): 379-388.

BackgroundPerioperative hypersensitivity reactions constitute a global health problem, with an estimated incidence of 1 per 100,000 procedures and a mortality rate of 0.1 to 9 %. Main risk factors are a history of allergy to other drugs, atopy, associated psychiatric disorders and previous surgeries.ObjectivesTo determine the frequency of sensitization and the type of drugs involved in perioperative allergy in a tertiary care hospital, over a 3-year period.MethodsRetrospective, cross-sectional, descriptive study of perioperative allergy, corroborated by skin tests for each drug and latex, of patients treated at the Allergy and Clinical Immunology Department of Hospital General de Mexico.ResultsTwenty-eight patients diagnosed with perioperative allergy were included. Main triggers were neuromuscular blocking agents (46.42 %), latex (28.52 %) and propofol (14.28 %). The main risk factor was a history of previous surgeries (89.28 %). Most perioperative allergic reactions were mild (71.42 %) and occurred within the postoperative period (60.71 %).ConclusionsInitial diagnosis and Treatment should always be carried out by the anesthesiologist or surgeon, who should focus on the withdrawal of possible causative agents.

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