• C Hobeika, D Fuks, F Cauchy, C Goumard, O Soubrane, B Gayet, E Salamé, D Cherqui, E Vibert, O Scatton, AFC-LLR-2018 study group, T Nomi, N Oudafal, T Kawai, S Komatsu, S Okumura, N Petrucciani, A Laurent, P Bucur, L Barbier, B Trechot, J Nunèz, M Tedeschi, M-A Allard, N Golse, O Ciacio, G Pittau, Cunha A Sa AS Centre Hépato-biliaire de Paul Brousse, APHP, Villejuif, France., R Adam, C Laurent, L Chiche, P Leourier, L Rebibo, J-M Regimbeau, L Ferre, F R Souche, J Chauvat, J-M Fabre, F Jehaes, K Mohkam, M Lesurtel, C Ducerf, J-Y Mabrut, T Hor, F Paye, P Balladur, B Suc, F Muscari, G Millet, M El Amrani, C Ratajczak, K Lecolle, E Boleslawski, S Truant, F-R Pruvot, A-R Kianmanesh, T Codjia, L Schwarz, E Girard, J Abba, C Letoublon, M Chirica, A Carmelo, C VanBrugghe, Z Cherkaoui, X Unterteiner, R Memeo, P Pessaux, E Buc, E Lermite, J Barbieux, M Bougard, U Marchese, J Ewald, O Turini, A Thobie, B Menahem, A Mulliri, J Lubrano, J Zemour, H Fagot, G Passot, E Gregoire, J Hardwigsen, Y-P le Treut, and D Patrice.
• Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Sorbonne Université, Centre de Recherche Scientifique Saint Antoine, Hôpital Pitié Salpétrière, Paris, France.
• Br J Surg. 2020 Feb 1; 107 (3): 268-277.

BackgroundThe aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study.MethodsThis retrospective study included all patients undergoing LLR in 27 centres between 2000 and 2017. Cirrhosis was defined as F4 fibrosis on pathological examination. Short-term outcomes of patients with and without liver cirrhosis were compared after propensity score matching by centre volume, demographic and tumour characteristics, and extent of resection.ResultsAmong 3150 patients included, LLR was performed in 774 patients with (24·6 per cent) and 2376 (75·4 per cent) without cirrhosis. Severe complication and mortality rates in patients with cirrhosis were 10·6 and 2·6 per cent respectively. Posthepatectomy liver failure (PHLF) developed in 3·6 per cent of patients with cirrhosis and was the major cause of death (11 of 20 patients). After matching, patients with cirrhosis tended to have higher rates of severe complications (odds ratio (OR) 1·74, 95 per cent c.i. 0·92 to 3·41; P = 0·096) and PHLF (OR 7·13, 0·91 to 323·10; P = 0·068) than those without cirrhosis. They also had a higher risk of death (OR 5·13, 1·08 to 48·61; P = 0·039). Rates of cardiorespiratory complications (P = 0·338), bile leakage (P = 0·286) and reoperation (P = 0·352) were similar in the two groups. Patients with cirrhosis had a longer hospital stay than those without (11 versus 8 days; P = 0·018). Centre expertise was an independent protective factor against PHLF in patients with cirrhosis (OR 0·33, 0·14 to 0·76; P = 0·010).ConclusionUnderlying cirrhosis remains an independent risk factor for impaired outcomes in patients undergoing LLR, even in expert centres.© 2020 BJS Society Ltd Published by John Wiley & Sons Ltd.

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