• Michaël J Bos, Wolfgang Buhre, Yasin Temel, JoostenElbert A JEAJDepartments of Anesthesiology and Pain Medicine.School for Mental Health and Neuroscience, Maastricht University, Maastricht., Anthony R Absalom, and JanssenMarcus L FMLFNeurology.Clinical Neurophysiology, Maastricht University Medical Center.School for Mental Health and Neuroscience, Maastricht University, Maastricht..
• Departments of Anesthesiology and Pain Medicine.
• J Neurosurg Anesthesiol. 2021 Oct 1; 33 (4): 300307300-307.

AbstractDeep brain stimulation (DBS) is an effective surgical treatment for patients with various neurological and psychiatric disorders. Clinical improvements rely on careful patient selection and accurate electrode placement. A common method for target localization is intraoperative microelectrode recording (MER). To facilitate MER, DBS surgery is traditionally performed under local or regional anesthesia. However, sedation or general anesthesia is sometimes needed for patients who are unable to tolerate the procedure fully awake because of severe motor symptoms, psychological distress, pain, or other forms of discomfort. The effect of anesthetic drugs on MER is controversial but likely depends on the type and dose of a particular anesthetic agent, underlying disease, and surgical target. In this narrative review, we provide an overview of the current literature on the anesthetic drugs most often used for sedation and anesthesia during DBS surgery, with a focus on their effects on MERs.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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