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- Giuseppe Lippi, Fabian Sanchis-Gomar, and Emmanuel J Favaloro.
- Section of Clinical Biochemistry, University of Verona, Verona, Italy.
- Trends Pharmacol. Sci. 2016 Jun 1; 37 (6): 413-414.
AbstractDespite direct oral anticoagulants becoming a mainstay of anticoagulant therapy, the effective, timely, and safe reversal of their anticoagulant effect remains challenging. Emerging evidence attests that andexanet, a recombinant and inactive variant of native factor X (FXa), competitively inhibits and counteracts the anticoagulant effect of many inhibitors of native activated FXa.Copyright © 2016 Elsevier Ltd. All rights reserved.
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