• van Reij R R I RRI Department of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands., Hoofwijk D M N DMN School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, University of Maastricht, the Netherlands., Rutten B P F BPF Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, University of Maastricht, the Netherlands., L Weinhold, M Leber, Joosten E A J EAJ Department of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands., A Ramirez, N J van den Hoogen, and Italian Pain Group.
• Department of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands.
• Anaesthesia. 2020 Jan 1; 75 Suppl 1: e111-e120.

AbstractChronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene-targeted analysis has been used to date. This is the first genome-wide association study to identify single-nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case-control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single-nucleotide polymorphisms reached genome-wide significance, but several showed suggestive associations with chronic postoperative pain (p < 1 × 10-5 ). Single-nucleotide polymorphisms with significance p < 1 × 10-5 were followed up in a replication cohort consisting of 203 men and women scheduled for orthopaedic or abdominal surgery. Ten of these patients developed severe chronic postoperative pain. A single-nucleotide polymorphism in NAV3 was significantly replicated with chronic postoperative pain in the replication cohort (p = 0.009). Meta-analysis revealed that two loci (IQGAP1 and CRTC3) were significantly associated with chronic postoperative pain at 3 months (IQGAP1 p = 3.93 × 10-6 β = 2.3863, CRTC3 p = 2.26 × 10-6 , β = 2.4209). The present genome-wide association study provides initial evidence for genetic risk factors of chronic postoperative pain and supports follow-up studies.©2020 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetist.

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