• Forensic Sci. Int. · Sep 1997

    Review Case Reports

    Lethal suicidal intoxication with propafenone, after a history of self-inflicted injuries.

    • H Maxeiner and E Klug.
    • Institute of Legal Medicine, UK Benjamin Franklin, Free University, Berlin, Germany.
    • Forensic Sci. Int. 1997 Sep 19; 89 (1-2): 27-32.

    AbstractReport of a suicidal mono-intoxication with the class IC antiarrythmic drug propafenone. A 20-year-old female physician's assistant secretly ingested the substance (presumably 20 tablets per 300 mg) about 4-6 h before her death, and in the interim remained under the supervision of her physician. An ECG taken about 1/2-2 h after ingestion showed widening of the QRS complex and signs of an acute load of the right ventricle; the clinical symptoms were nausea, vomiting and hypotonia. After about 4 h without serious symptoms acute loss of consciousness and cardiac failure occurred, resuscitation efforts remained unsuccessful. At autopsy propafenone was found in blood (12 micrograms ml-1), liver (60 micrograms g-1) and cardiac muscle (11 micrograms g-1).

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