• Philip J O'Halloran, Michael Amoo, Dablouk Mohamed O MO Department of Neurosurgery, National Neurosurgical Centre, Beaumont Hospital, Dublin, Ireland., Alan Beausang, and Stephen MacNally.
• Department of Neurosurgery, National Neurosurgical Centre, Beaumont Hospital, Dublin, Ireland; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: philohalloran@rcsi.ie.
• World Neurosurg. 2020 Apr 1; 136: 110-116.

BackgroundAngiocentric glioma (AG) is an epileptogenic low grade (World Health Organization grade I) glial tumor with astrocytic and ependymal differentiation, most commonly affecting the pediatric and adolescent population. Despite its infiltrating histological growth kinetics, it is widely accepted that AG has a low potential for aggressive behavior.Case DescriptionWe present the case of a 42-year-old man who represents the first documented case of not only extracranial manifestation of AG, but also spinal metastatic dissemination. Our patient initially presented with a generalized tonic clonic seizure; following a biopsy, he was diagnosed with a low-grade supratentorial astrocytoma and subsequently received fractionated radiotherapy. He presented 10 months later with worsening dorsal column symptoms and was found to have a contrast-enhancing intradural extramedullary lesion that was surgically resected and histologically confirmed as an AG.ConclusionFurther research is required to examine the microenvironment and potential for malignant change in this tumor.Copyright © 2020 Elsevier Inc. All rights reserved.

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