• Liuwei Chen and Quanbin Zhang.
• Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
• World Neurosurg. 2020 May 1; 137: e118-e125.

ObjectiveTo assess whether mean platelet volume (MPV) is associated with functional outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH).MethodsWe retrospectively collected and analyzed data from patients with aSAH who were treated at our institution between January 2015 and January 2019. The patients were divided into 2 groups according to their modified Rankin Scale (mRS) score at 3 months. Univariate and multivariate analyses were performed to investigate whether MPV was associated with poor prognosis. Receiver operating characteristic (ROC) curve analysis was performed to indicate the value of MPV for the prediction of functional outcome in these patients.ResultsA total of 262 patients were included in this study. Multivariate logistic regression analysis identified MPV as an independent predictor of poor functional outcome (odds ratio, 2.777; 95% confidence interval [CI], 1.255-6.145; P = 0.012). ROC analysis revealed that MPV could predict poor functional outcome at 3 months, with an area under the curve of 0.803 (95% CI, 0.739-0.867; P < 0.001). Patients with higher MPV values on admission tended to have a higher Hunt-Hess grade (P < 0.001) and Fisher grade (P < 0.001); higher rates of acute hydrocephalus (P = 0.001), shunt-dependent hydrocephalus (P < 0.001), and delayed cerebral ischemia (P < 0.001); and higher mortality (P < 0.001).ConclusionsMPV is an independent predictor of unfavorable functional outcome at 3 months in patients with aSAH.Copyright © 2020. Published by Elsevier Inc.

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