• Jun Hyun Kim, Caterina Cecilia Lerose, Giovanni Landoni, Ambra Licia Di Prima, Margherita Licheri, Alessandro Oriani, Moad Alaidroos, Alberto Zangrillo, and Fabrizio Monaco.
• Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
• J. Cardiothorac. Vasc. Anesth. 2020 Mar 1; 34 (3): 650-658.

ObjectiveTo find out if there are any differences in biomarkers between severe isolated right ventricular (RV) dysfunction and severe isolated left ventricular (LV) dysfunction after cardiac surgery using cardiopulmonary bypass.DesignObservational study.SettingTeaching hospital.ParticipantsA total of 46 patients who had severe isolated RV or LV dysfunction after cardiac surgery.InterventionThe authors collected perioperative clinical and biomarker data.Measurements And Main ResultsSevere isolated RV dysfunction patients (n = 20) had higher postoperative direct bilirubin (p = 0.030), total bilirubin (p = 0.044), glucose (p = 0.011), and international normalized ratio (INR) (p = 0.050) by repeated measure analysis of variance when compared with patients with severe isolated LV dysfunction (n = 26). The RV group also showed lower preoperative alanine transferase (19.3 ± 1.5 v 32.7 ± 4.2, p = 0.001), higher 4-hour INR (1.5 ± 0.3 v 1.4 ± 0.2, p = 0.008), and higher 48-hour INR (1.8 ± 0.4 v 1.4 ± 0.1, p < 0.001). None in the LV group died, whereas 4 patients in the RV group died (all of them had preoperative atrial fibrillation and underwent double valve replacement surgery).ConclusionThe authors observed biomarkers differences between severe isolated RV dysfunction and severe isolated RV dysfunction.Copyright © 2019 Elsevier Inc. All rights reserved.

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