• Ryoung-Eun Ko, Jeong-Am Ryu, Yang Hyun Cho, Kiick Sung, Kyeongman Jeon, Gee Young Suh, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Keumhee C Carriere, Joonghyun Ahn, and Jeong Hoon Yang.
• Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
• Resuscitation. 2020 Mar 1; 148: 121-127.

BackgroundLimited data is available on the association between low-flow time and neurologic outcome according to the initial arrest rhythm in patients underwent extracorporeal cardiopulmonary resuscitation (ECPR).MethodsBetween September 2004 and December 2018, 294 patients with in-hospital cardiac arrest (IHCA) were included in this analysis. We classified the patients into asystole (n = 42), pulseless electrical activity (PEA, n = 163) and shockable rhythm (n = 89) according to their initial rhythm. Primary outcome was poor neurologic outcome defined as Cerebral Performance Categories scores of 3, 4, and 5.ResultsOne-hundred ninety IHCA patients (64.6%) had poor neurologic outcomes. There was significantly worse neurologic outcomes among IHCA patients according to their initial rhythm (asystole [88.1%], PEA [66.3%], and shockable rhythm [50.6%], p < 0.001). The PEA group and the shockable rhythm group showed a significant association between low-flow time and neurologic outcomes while this relationship was not observed in the asystole group: PEA [ρ = 0.224, p = 0.005], shockable rhythm [ρ = 0.298, p = 0.006]), and asystole [ρ = -0.091, p = 0.590]. The best discriminative CPR to pump-on time for neurologic outcome was 22 min in the PEA group (area under the curve 0.687, 95% confidence interval [CI] 0.610-0.758, p < 0.001) and 46 min in the shockable rhythm group (area under the curve 0.671, 95% CI 0.593-0.743, p < 0.001).ConclusionsThe effect of interplay between arrest rhythm and low-flow time might be helpful for decisions about team activation and management for ECPR and could provide information for early neurologic prognosis.Copyright © 2020 Elsevier B.V. All rights reserved.

9 keywords...

hide…