Hemodynamic response to β-blockers in severe sepsis and septic

Journal of critical care · Apr 2019

Review

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

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- Lex M van Loon, Johannes G van der Hoeven, and Joris Lemson.
- Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Science, Technical Medical Centre, University of Twente, Postbox 217, 7500 AE Enschede, the Netherlands; Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands. Electronic address: l.m.vanloon@utwente.nl.
- J Crit Care. 2019 Apr 1; 50: 138-143.
AbstractThe administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.Copyright © 2018 Elsevier Inc. All rights reserved.

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Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature.

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