• Ann. Surg. Oncol. · Jun 2012

    Review

    Hereditary breast and ovarian cancer and other hereditary syndromes: using technology to identify carriers.

    • Brian Drohan, Constance A Roche, James C Cusack, and Kevin S Hughes.
    • Division of Surgical Oncology, Department of Surgery, Avon Comprehensive Breast Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    • Ann. Surg. Oncol. 2012 Jun 1; 19 (6): 1732-7.

    Purpose And MethodsMost patients who harbor a genetic mutation for hereditary breast cancer have not been identified, despite the availability of genetic testing. Developing an effective approach to the identification of high-risk individuals is the key to preventing and/or providing early diagnosis of cancer in this patient population. This educational review addresses these issues.Results And DiscussionUsing data available on the internet, and making assumptions regarding the types and results of genetic testing, we have estimated the number of mutation carriers in the country and the number who have been tested and identified as such. Overall, our ability to fund and more effectively manage carriers is weak. A technological solution is discussed.

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