• Expert Opin Pharmacother · Oct 2009

    Review

    Multidisciplinary treatment of locally advanced rectal cancer: a literature review. Part 1.

    • Rossana Berardi, Elena Maccaroni, Azzurra Onofri, Riccardo Giampieri, Alessandro Bittoni, Mirco Pistelli, Mario Scartozzi, Chiara Pierantoni, Maristella Bianconi, and Stefano Cascinu.
    • Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G Salesi di Ancona, Medical Oncology Unit, Ancona, Italy. r.berardi@univpm.it
    • Expert Opin Pharmacother. 2009 Oct 1; 10 (14): 2245-58.

    AbstractIn Western countries, colorectal cancer is the third most common cancer in terms of incidence and mortality. The management of rectal cancer has undergone and continues to undergo significant evolutions. In the last two decades, new multimodality strategies have been developed. Multimodality treatments have improved the prognosis of locally advanced rectal cancer with local recurrences decreasing from 40% to < 10% and overall survival increasing from 50% to 75% in the last 40 years. This review discusses the role of neoadjuvant chemoradiotherapy regimens used in the standard combined modality treatment programs for rectal cancer and focuses on the ongoing research to improve these regimens.

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