• Arterioscler. Thromb. Vasc. Biol. · Jul 2018

    IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report.

    • Jeffrey M Wilson, Anh T Nguyen, Alexander J Schuyler, Scott P Commins, Angela M Taylor, Platts-Mills Thomas A E TAE From the Division of Allergy and Immunology (J.M.W., A.J.S., T.A.E.P.-M.) tap2z@virginia.edu cam8c@virginia.edu., and Coleen A McNamara.
    • From the Division of Allergy and Immunology (J.M.W., A.J.S., T.A.E.P.-M.).
    • Arterioscler. Thromb. Vasc. Biol. 2018 Jul 1; 38 (7): 1665-1669.

    ObjectiveEmerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease.Approach And ResultsTotal IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound. IgE to α-Gal was detected in 26%, and atheroma burden was higher in sensitized subjects (P=0.02). Because α-Gal sensitization relates to an environmental exposure that could be a risk factor for early-onset coronary artery disease (ie, tick bites), we age stratified the cohort. In subjects ≤65 years of age, the strength of the association with atheroma burden was stronger (P<0.001), and plaques in the sensitized group had less stable features based on intravascular ultrasound. To address the specificity of the association with IgE to α-Gal, IgE to inhalants and peanut were assayed and were not associated with coronary artery disease. Total IgE and α-Gal-specific IgE were strongly associated with each other, but the strength of the relationship with atheroma burden was stronger for α-Gal-specific IgE. This association was significant when adjusted for sex, diabetes mellitus, hypertension, statin use, and total IgE (regression coefficient, 12.2; SE, 5.2; P=0.02).ConclusionsIncreased atheroma burden and plaques with more unstable features were associated with IgE to α-Gal-an effect most pronounced in subjects ≤65 years of age. IgE sensitization to α-Gal may represent a novel, and potentially modifiable, risk factor for coronary atherosclerosis.© 2018 American Heart Association, Inc.

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