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- Adriaan H de Wilde, Darryl Falzarano, Jessika C Zevenhoven-Dobbe, Corrine Beugeling, Craig Fett, Cynthia Martellaro, Clara C Posthuma, Heinz Feldmann, Stanley Perlman, and Eric J Snijder.
- Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: A.H.de_Wilde@lumc.nl.
- Virus Res. 2017 Jan 15; 228: 7-13.
AbstractCurrently, there is no registered treatment for infections with emerging zoonotic coronaviruses like SARS- and MERS-coronavirus. We here report that in cultured cells low-micromolar concentrations of alisporivir, a non-immunosuppressive cyclosporin A-analog, inhibit the replication of four different coronaviruses, including MERS- and SARS-coronavirus. Ribavirin was found to further potentiate the antiviral effect of alisporivir in these cell culture-based infection models, but this combination treatment was unable to improve the outcome of SARS-CoV infection in a mouse model. Nevertheless, our data provide a basis to further explore the potential of Cyp inhibitors as host-directed, broad-spectrum inhibitors of coronavirus replication.Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
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