• Yuta Nakanishi, Kentaro Naito, Toru Yamagata, and Toshihiro Takami.
• Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
• World Neurosurg. 2020 Apr 1; 136: e614-e624.

ObjectiveHealth-related quality of life (HRQOL) after surgery for spinal intramedullary benign encapsulated tumors remains unclear. A single-institute, 3-year, prospective study was conducted to examine HRQOL after microscopic total removal of spinal intramedullary ependymomas using a safe and precise strategy.MethodsA cohort of 20 patients with a possible diagnosis of spinal intramedullary benign ependymomas was recruited. Patients who underwent microscopic total removal of the tumor and for whom the pathologic diagnosis was verified as World Health Organization grade II benign ependymoma were included. Sixteen patients (average age, 48.7 years) were eligible for study analysis. Careful assessment was performed for all patients before and 6-12 months after surgery. The 36-Item Short Form Health Survey was used to assess HRQOL, with the surveyor recording answers as reported by the individual patient.ResultsAverage total HRQOL score was 431.1 before surgery and was maintained at 434.2 at 6-12 months postoperatively. Patients with mild functional symptoms tended to demonstrate a higher total HRQOL score preoperatively compared with patients with moderate to severe functional symptoms. A strong correlation was noted between postoperative functional conditions and preservation of HRQOL.ConclusionsThis is the first study focusing on HRQOL after microscopic total removal of spinal intramedullary ependymomas. This study suggested that radical surgery using a safe and precise strategy appears justifiable and that preservation of neurologic function after surgery may lead to maintenance of postoperative HRQOL.Copyright © 2020 Elsevier Inc. All rights reserved.

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