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Stereotact Funct Neurosurg · Jan 2010
Case ReportsThalamic deep brain stimulation for the treatment of action myoclonus caused by perinatal anoxia.
- Kazutaka Kobayashi, Yoichi Katayama, Toshiharu Otaka, Toshiki Obuchi, Toshikazu Kano, Takafumi Nagaoka, Masahiko Kasai, Hideki Oshima, Chikashi Fukaya, and Takamitsu Yamamoto.
- Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan. kitta@med.nihon-u.ac.jp
- Stereotact Funct Neurosurg. 2010 Jan 1; 88 (4): 259-63.
BackgroundPerinatal anoxia rarely causes myoclonus as the main neurologic abnormality. The exact neuronal mechanism underlying myoclonus induced by perinatal anoxia remains unknown. Some studies have indicated that the development of involuntary movements may be related to the maturation of the thalamus after birth.Objectives And MethodsHere, we describe the first case of a patient who developed action myoclonus after experiencing perinatal anoxia and was successfully treated by chronic deep brain stimulation (DBS) of the thalamus (thalamic DBS).Results And ConclusionThe effectiveness of chronic thalamic DBS in this patient supports the concept of involvement of the thalamus in post-perinatal anoxic myoclonus.2010 S. Karger AG, Basel.
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