• Yoichi Shimada, Akira Kitamura, Kazuhiro Nakanishi, Takashi Hongo, Chol Kim, and Atsuhiro Sakamoto.
• Department of Anesthesiology, Nippon Medical School Second Hospital, Kanagawa, Japan. megu@nms.ac.jp
• J Nippon Med Sch. 2005 Dec 1; 72 (6): 364-9.

AimThe present study was designed to assess whether prophylactic use of bicarbonated Ringer's solution ameliorates metabolic acidosis in patients undergoing aortic surgery.MethodsTwenty patients undergoing elective infrarenal aortic aneurysm repair were randomly assigned to receive either bicarbonated Ringer's solution or acetated Ringer's solution. The pH, PaCO(2), and base excess (BE) were measured before surgical incision (T0), 5 min before reperfusion (T1), 5 min after reperfusion (T2), and 30 min after reperfusion (T3). Data were compared between the two groups.ResultsBoth pH and BE initially showed a slight decrease in both groups during clamping. After unclamping of the aorta, an additional decrease in pH was observed in both groups (T0 to T2, and T3). There were no significant differences in pH between the groups throughout the study period.ConclusionsAortic cross-clamping leads to the development of metabolic acidosis, with a decrease in pH and BE. The effect of administration of bicarbonated infusion fluid during elective abdominal aortic surgery had not significant compared with that of acetated Ringer's solution with respect to acid-base homeostasis.

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