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Review
Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy.
- Elizabeth Ashley Hardin and Kelly M Chin.
- Department of Internal Medicine, Division of Cardiology.
- Drug Des Dev Ther. 2016 Jan 1; 10: 3747-3754.
AbstractPulmonary arterial hypertension is characterized by abnormalities in the small pulmonary arteries including increased vasoconstriction, vascular remodeling, proliferation of smooth muscle cells, and in situ thrombosis. Selexipag, a novel, oral prostacyclin receptor agonist, has been shown to improve hemodynamics in a phase II clinical trial and reduce clinical worsening in a large phase III clinical trial involving patients with pulmonary arterial hypertension. In this paper, we describe the prostacyclin signaling pathway, currently available oral prostanoid medications, and the development and clinical use of selexipag.
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