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Review
Immune checkpoint inhibitors: a narrative review of considerations for the anaesthesiologist.
- Alexandra L Lewis, Jamie Chaft, Monica Girotra, and Gregory W Fischer.
- Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: lewisa1@mskcc.org.
- Br J Anaesth. 2020 Mar 1; 124 (3): 251260251-260.
AbstractImmunotherapy has revolutionised the treatment of oncologic malignancies. Immune checkpoint inhibitors represent a new class of immunotherapy drugs. Although these drugs show promise, they are associated with immune-related adverse reactions. An increasing number of patients who undergo surgery will have had treatment with immune checkpoint inhibitors. In this narrative review article, we discuss their mechanism of action, therapeutic effects, pertinent toxicities, and address specific perioperative considerations for patients treated with immune checkpoint inhibitors.Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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