• Alisha Young, Paul E Marik, Steven Sibole, David Grooms, and Alex Levitov.
• Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
• J. Cardiothorac. Vasc. Anesth.. 2013 Aug 1;27(4):681-4.

ObjectiveThe purpose of this study was to determine whether changes in PETCO2 and exhaled CO2 (VCO2) can predict fluid responsiveness after a preload challenge.DesignA retrospective review of prospectively recorded data.SettingA medical intensive care unit of a university-affiliated tertiary care hospital.ParticipantsMechanically ventilated patients undergoing a preload challenge.InterventionsIn the authors' intensive care unit, fluid responsiveness is determined by a passive leg raising (PLR) maneuver and/or a 500-mL crystalloid challenge. An increase in the stroke volume index >10% as measured by a NICOM bioreactance cardiac output monitor (Cheetah Medical, Inc, Vancouver, WA) is used to determine fluid responsiveness. PETCO2 and volumetric capnography (VCO2) were monitored via a combined CO2 and flow sensor capnostat (Respironics NM3 Monitor; Philips Healthcare, Eindhoven, Netherlands). Patients were mechanically ventilated with tidal volumes controlled at 8 mL/kg, allowing for consistent minute ventilation.Measurements And Main ResultsDuring the study period, 44 challenges (10 PLR and 34 fluid boluses) were performed on 34 patients. There were 24 (54%) positive "fluid" responses. PETCO2 increased by 5.9% ± 7.6% in the responders compared with 1.4% ± 4.4% in the nonresponders (p = 0.02). Similarly, VCO2 increased by 11.0% ± 8.6% in the responders compared with 0.8% ± 5.6% in the nonresponders (p = 0.001). The area under the receiver operating characteristic curve was 0.67 (95% confidence interval, 0.48-0.80) for PETCO2 and 0.79 (95% confidence interval, 0.63-0.89) for VCO2. PETCO2 and VCO2 were predictive of fluid responsiveness only in those patients without underlying lung disease. The stroke volume variation was 15.8 ± 3.7 in the responders compared with 13.6 ± 4.8 in the nonresponders (p = 0.15).ConclusionsDynamic changes in PETCO2 and VCO2 may be used as adjunctive indicators of fluid responsiveness in patients without underlying lung disease.Copyright © 2013 Elsevier Inc. All rights reserved.

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