• Harleen Kaur, Nakul Katyal, Anudeep Yelam, Keerthana Kumar, Hirsch Srivastava, and Raghav Govindarajan.
• Harleen Kaur, MBBS, Nakul Katyal, MD, Anudeep Yelam, MBBS, Keerthana Kumar, MBBS, and Raghav Govindarajan, MD, MSMA member since 2013, are in the Department of Neurology, University of Missouri School of Medicine.
• Mo Med. 2019 Mar 1; 116 (2): 154-159.

AbstractMalignant Hyperthermia (MH) is a life-threatening pharmacogenetic disorder which results from exposure to volatile anesthetic agents and depolarizing muscle relaxants. It manifests as a hypermetabolic response resulting in tachycardia, tachypnea, hyperthermia, hypercapnia, acidosis, muscle rigidity and rhabdomyolysis. An increase in the end-tidal carbon dioxide is one of the earliest diagnostic signs. Dantrolene sodium is effective in the management of MH, and should be available whenever general anesthesia is administered. This review also aims to highlight the genetics and pathology of MH, along with its association with various inherited myopathy syndromes like central core disease, multi-mini core disease, Native-American myopathy, and King-Denborough syndrome.

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