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Minerva anestesiologica · Jun 2020
Levosimendan to facilitate weaning from cardiorespiratory support in critically ill patients: current evidence and future directions.
- Fabio Sangalli, Giacomo Bellani, Alessandro Affronti, Francesca Volpi, Marco Feri, Marco Marini, Antonio Quacquarelli, Domenico Vitale, and Fabio Guarracino.
- ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy - fabio.sangalli@unimib.it.
- Minerva Anestesiol. 2020 Jun 1; 86 (6): 645-651.
AbstractAppropriate weaning is of crucial importance for critically ill patients requiring respiratory support. However, a remarkable proportion of them are difficult to wean. Levosimendan is a positive inotropic agent characterized by vasodilatory properties, which is used for the treatment of acute decompensated heart failure or in patients needing inotropic treatment, including cardiogenic shock, septic shock, pulmonary hypertension and right ventricular dysfunction, needed for hemodynamic support in patients with diuretic resistance, and weaning either from ventilator or from extracorporeal membrane oxygenation. This position paper will discuss the use of levosimendan in facilitating weaning from cardiorespiratory support in critically ill patients, according to available evidence and the personal experience of a group of Italian Experts.
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