• Neurosci Biobehav Rev · Apr 2019

    Review

    The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish.

    • Rafael Genario, Ana C V V Giacomini, Konstantin A Demin, Bruna E Dos Santos, Natalia I Marchiori, Angrey D Volgin, Alim Bashirzade, Tamara G Amstislavskaya, Murilo S de Abreu, and Allan V Kalueff.
    • Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
    • Neurosci Biobehav Rev. 2019 Apr 1; 99: 117-127.

    AbstractMelatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.Copyright © 2019 Elsevier Ltd. All rights reserved.

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