• Shock · Sep 2008

    Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats.

    • Tatiana Carolina Alba-Loureiro, Tania Cristina Pithon-Curi, and Rui Curi.
    • Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil. tatica@icb.usp.br
    • Shock. 2008 Sep 1; 30 (3): 308-10.

    AbstractIL-1beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.

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