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The lancet oncology · Sep 2011
ReviewUse of antineoplastic agents in patients with cancer who have HIV/AIDS.
- Michelle A Rudek, Charles Flexner, and Richard F Ambinder.
- Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. mrudek2@jhmi.edu
- Lancet Oncol. 2011 Sep 1; 12 (9): 905-12.
AbstractHighly active antiretroviral therapy (HAART) has substantially reduced morbidity and mortality of AIDS-related complications in patients with HIV; however, the prevalence of AIDS-defining cancers and non-AIDS-defining cancers has increased. In this Review we discuss the management of HAART pharmacotherapy in relation to cytotoxic chemotherapy or targeted antineoplastic agents. We will review potential pharmacological interactions between antiretroviral and antineoplastic therapies and consider how to combine antiretroviral and antineoplastic agents in patients with HIV who are receiving HAART therapy.Copyright © 2011 Elsevier Ltd. All rights reserved.
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