The Distal Spine: Normal Embryogenesis and Derangements

Neuroimaging Clin. N. Am. · Aug 2019

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The Distal Spine: Normal Embryogenesis and Derangements Leading to Malformation.

The spine and spinal cord are composed of multiple segments initiated by different embryologic mechanisms and advanced under different systems of control. In humans, the upper central nervous system is formed by primary neurulation, the lower by secondary neurulation, and the intervening segment by junctional neurulation. This article focuses on the distal spine and spinal cord to address their embryogenesis and the molecular derangements that lead to some distal spinal malformations.

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- Thomas P Naidich, Javin Schefflein, Mario A Cedillo, Jacob P Deutsch, Shashidhara Murthy, and Mary Fowkes.
- Department of Radiology, Icahn School of Medicine at Mt. Sinai, One Gustave Levy Place, New York, NY 10029, USA. Electronic address: thomas.naidich@mountsinai.org.
- Neuroimaging Clin. N. Am. 2019 Aug 1; 29 (3): 385-409.
AbstractThe spine and spinal cord are composed of multiple segments initiated by different embryologic mechanisms and advanced under different systems of control. In humans, the upper central nervous system is formed by primary neurulation, the lower by secondary neurulation, and the intervening segment by junctional neurulation. This article focuses on the distal spine and spinal cord to address their embryogenesis and the molecular derangements that lead to some distal spinal malformations.Copyright © 2019 Elsevier Inc. All rights reserved.

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