• Neuroimaging Clin. N. Am. · Aug 2019

    Review

    Connectomics in Brain Malformations: How Is the Malformed Brain Wired?

    • Avner Meoded and Huisman Thierry A G M TAGM Edward B. Singleton Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 470, Houston, TX 77030, USA..
    • Pediatric Radiology and Neuroradiology, Johns Hopkins University School of Medicine, Johns Hopkins All Children's Hospital, 501 Sixth Avenue South, St Petersburg, FL 33701, USA. Electronic address: ameoded1@jhmi.edu.
    • Neuroimaging Clin. N. Am. 2019 Aug 1; 29 (3): 435-444.

    AbstractA new neuroimaging dimension is currently being adopted. The structural connectome reveals macroscale white matter connectivity of the human brain, providing insights into brain networks organization. Connectomics (analysis of the connectome) has potential for elucidating aberrant networks (eg, in congenital brain malformations, especially axonal pathfinding disorders). Connectomics provides a powerful set of network measures, which can serve as noninvasive biomarkers for the diagnosis, prognostication, and treatment response of children. We discuss the principles of connectome reconstruction and visualization of the pediatric structural connectome using current state-of-the-art neuroimaging and postprocessing techniques, and we describe potential connectomics applications to study brain malformations.Copyright © 2019 Elsevier Inc. All rights reserved.

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