• Laure Doukhan, Magali Bisbal, Laurent Chow-Chine, Antoine Sannini, Jean Paul Brun, Sylvie Cambon, Lam Nguyen Duong, Marion Faucher, and Djamel Mokart.
• Intensive Care Unit, Institut Paoli Calmettes, Marseille, France.
• Plos One. 2017 Jan 1; 12 (7): e0181808.

IntroductionPrognostic impact of delayed intensive care unit(ICU) admission in critically ill cancer patients remains debatable. We determined predictive factors for later ICU admission and mortality in cancer patients initially not admitted after their first ICU request.MethodsAll cancer patients referred for an emergency ICU admission between 1 January 2012 and 31 August 2013 were included.ResultsTotally, 246(54.8%) patients were immediately admitted. Among 203(45.2%) patients denied at the first request, 54(26.6%) were admitted later. A former ICU stay [OR: 2.75(1.12-6.75)], a request based on a clinical respiratory event[OR: 2.6(1.35-5.02)] and neutropenia[OR: 2.25(1.06-4.8)] were independently associated with later ICU admission. Survival of patients admitted immediately and later did not differ at ICU(78.5% and 70.4%, respectively; p = 0.2) or hospital(74% and 66%, respectively; p = 0.24) discharge. Hospital mortality of patients initially not admitted was 29.7% and independently associated with malignancy progression[OR: 3.15(1.6-6.19)], allogeneic hematopoietic stem cell transplantation[OR: 2.5(1.06-5.89)], a request based on a clinical respiratory event[OR: 2.36(1.22-4.56)] and severe sepsis[OR: 0.27(0.08-0.99)].ConclusionCompared with immediate ICU admission, later ICU admission was not associated with hospital mortality. Clinical respiratory events were independently associated with both later ICU admission and hospital mortality.

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