• Collin Tebo, Maryann Mazer-Amirshahi, Mark S Zocchi, Colin Gibson, Sarah Rosenwohl-Mack, Renee Y Hsia, Erin R Fox, Lewis S Nelson, and Jesse M Pines.
• Georgetown University School of Medicine, Washington, DC, United States of America. Electronic address: ct639@georgetown.edu.
• Am J Emerg Med. 2021 Apr 1; 42: 137-142.

ObjectiveWe determine how aggregate costs have changed for commonly used emergency department (ED) medications, and assess drivers of cost increases.MethodsUsing the National Hospital Ambulatory Medical Care Survey (NHAMCS), we identified the top 150 ED medications administered and prescribed at discharge in 2015. We used average wholesale prices (AWP) for each year from 2006 to 15 from the Red Book (Truven Health Analytics Inc.). Average wholesale price per patient (AWPP) was calculated by dividing AWP by drug uses. This was then multiplied by the total drug administrations or prescriptions to estimate the total cost in a given the year. All prices were converted to 2015 dollars.ResultsAggregate costs of drugs administered in the ED increased from $688.7 million in 2006 to $882.4 million in 2015. For discharge prescriptions, aggregate costs increased from $2.031 billion in 2006 to $4.572 billion in 2015. AWPP for drugs administered in the ED in 2015 was 14.5% higher than in 2006 and 24.3% higher at discharge. The largest absolute increase in AWPP for drugs administered was for glucagon, which increased from $111 in 2006 to $235 in 2015. The largest AWPP increase at discharge was for epinephrine auto-injector, which increased from $124 in 2006 and to $481 in 2015.ConclusionOver the course of the study period, the aggregate costs of the most common medications administered in the ED increased by 28% while the costs of medications prescribed at discharge increased 125%.Copyright © 2020. Published by Elsevier Inc.

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