• Jung Hwoon Edward Yoon, Vadim Grechushkin, Ammar Chaudhry, Priya Bhattacharji, Brian Durkin, and William Moore.
• Department of Radiology, State University of New York at Stony Brook, University Hospital, HSC Level IV, Room 060, Stony Brook, NY 11794.
• J Vasc Interv Radiol. 2016 Feb 1; 27 (2): 239-43.

PurposeTo evaluate the safety and efficacy of cryoneurolysis in patients with refractory peripheral neuropathic pain.Materials And MethodsTwenty-two patients referred for cryoneurolysis of refractory peripheral neuropathy were recruited prospectively from July 2011 to July 2013. The mean patient age was 49.5 years, and 41% of patients were female. Ultrasound imaging of the involved nerves was used for guidance. Percutaneous ablations were performed with a PerCryo 17R device. Pain levels were recorded on a visual analog scale (scores 0-10) before and at 1, 3, 6, 9, and 12 months after the procedure, and complications were documented.ResultsMean pain levels were 8.3 ± 1.9 before intervention and 2.3 ± 2.5 at 1 month, 3.2 ± 2.5 at 3 months, 4.7 ± 2.7 at 6 months, and 5.1 ± 3.7 at 12 months afterward. A Wilcoxon rank-sum test was performed and showed a statically significant decrease between pre- and postprocedural pain scores. There were no complications from the procedures.DiscussionCryoneurolysis caused a significant decrease in self-reported pain scores in patients with chronic refractory neuropathic pain, with moderately long-term relief. Cryoneurolysis is an additional therapy that can alleviate severe chronic neuropathic pain.Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.

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