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- Marianne C Wallis, Jonathan H Chow, Michael E Winters, and Michael T McCurdy.
- Division of Pulmonary and Critical Care, University of Maryland School of Medicine, Baltimore, Maryland, USA Mariannewallis@gmail.com.
- Emerg Med J. 2020 Nov 1; 37 (11): 717-721.
AbstractRefractory hypotension is one of the most common and difficult clinical problems faced by acute care clinicians, and it poses a particularly large problem to the emergency physician when a patient in undifferentiated shock arrives in the department. Angiotensin II (Ang-2) has been previously used as a vasopressor to combat shock; the feasibility of its clinical use has been reinvigorated after approval of a human synthetic formulation of the medication by the US Food and Drug Administration in 2017 and the European Medicines Agency in 2019. A thorough literature search was completed, and in this review, we discuss the discovery and development of Ang-2, its complex mechanisms of vasoconstriction, its potential adverse effects and its potential role in clinical practice for emergency physicians.© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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