• World Neurosurg · May 2020

    Observational Study

    Microdiscectomy for lumbar disc herniation - a single center observational study.

    • Vetle Vangen-Lønne, Mattis A Madsbu, Øyvind Salvesen, Øystein P Nygaard, Tore K Solberg, and Sasha Gulati.
    • Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: vetleva@ntnu.no.
    • World Neurosurg. 2020 May 1; 137: e577-e583.

    ObjectiveTo examine outcomes and complications following first-time lumbar microdiscectomy.MethodsProspective data for patients operated on between May 2007 and July 2016 were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in Oswestry Disability Index (ODI) score at 1 year. Secondary endpoints were change in quality of life measured with EuroQol 5 Dimensions, back and leg pain measured with numeric rating scales, and perioperative complications within 3 months of surgery.ResultsFor all enrolled patients (N = 1219) enrolled, mean improvement in ODI at 1 year was 33.3 points (95% confidence interval [CI] 31.7 to 34.9, P < 0.001). Mean improvement in EuroQol 5 Dimensions at 1 year of 0.52 point (95% CI 0.49 to 0.55, P < 0.001) represents a large effect size (Cohen's d = 1.6). Mean improvements in back pain and leg pain numeric rating scales were 3.9 points (95% CI 3.6 to 4.1, P < 0.001) and 5.0 points (95% CI 4.8 to 5.2, P < 0.001), respectively. There were 18 surgical complications in 1219 patients and 63 medical complications in 846 patients. The most common complication was micturition problems at 3 months following surgery (n = 25, 2.1%). In multivariate analysis, ODI scores of 21-40 (hazard ratio [HR] 14.5, 95% CI 1.1 to 27.9, P = 0.035), 41-60 (HR 27.5, 95% CI 13.4 to 41.7, P < 0.001), 61-80 (HR 47.4, 95% CI 33.4 to 61.4, P < 0.001) and >81 (HR 66.7, 95% CI 51.1 to 82.2, P < 0.001) were identified as positive predictors for ODI improvement at 1 year, whereas age ≥65 (HR -0.9, 95% CI -0.3 to -1.5, P = 0.004) was identified as a negative predictor for ODI improvement.ConclusionsMicrodiscectomy for lumbar disc herniation is an effective and safe treatment.Copyright © 2020 Elsevier Inc. All rights reserved.

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