• Molecules · Dec 2017

    Design of New-Generation Usable Forms of Topical Haemostatic Agents Containing Chitosan.

    • Dorota Zielińska, Marcin H Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona, and Kinga Brzoza-Malczewska.
    • R&D Project Department, Institute of Security Technologies MORATEX, Lodz 90-505, Poland. dzielinska@moratex.eu.
    • Molecules. 2017 Dec 15; 22 (12).

    AbstractDesigning usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex. Risk analysis is helpful in developing an appropriate research programme, significantly reducing the risk to an acceptable level.

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