• PharmacoEconomics · Nov 2013

    Review Comparative Study

    Cost effectiveness of treatments for stroke prevention in atrial fibrillation: focus on the novel oral anticoagulants.

    • Charalampos Kasmeridis, Stavros Apostolakis, Lars Ehlers, Lars H Rasmussen, Giuseppe Boriani, and Gregory Y H Lip.
    • University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, UK.
    • Pharmacoeconomics. 2013 Nov 1; 31 (11): 971-80.

    AbstractFor more than 5 decades, the only available treatment for the prevention of atrial fibrillation (AF)-related stroke were the vitamin K antagonists. Recently, novel oral anticoagulants (NOAC) have been approved for the prevention of AF-related stroke. In the present article, the cost effectiveness of AF-related stroke-prevention strategies is reviewed. The emphasis on NOACs aims to provide an overview of their impact on health economics based on the published cost-effectiveness analyses. The available evidence suggests that the balance from the efficacy and safety point of view makes the treatment with the NOACs a cost-effective alternative to warfarin. Thus, the NOACs offer efficacy, safety and convenience, as well as cost effectiveness, for stroke prevention in AF.

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