• Miroslaw Brys, Michael D Fox, Shashank Agarwal, Milton Biagioni, Geraldine Dacpano, Pawan Kumar, Elizabeth Pirraglia, Robert Chen, Allan Wu, Hubert Fernandez, Aparna Wagle Shukla, Jau-Shin Lou, Zachary Gray, David K Simon, Alessandro Di Rocco, and Alvaro Pascual-Leone.
• From the New York University School of Medicine (M.B., S.A., M.B., G.D., P.K., A.D.R.), Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, Department of Neurology, New York; Berenson-Allen Center for Noninvasive Brain Stimulation (M.D.F., Z.G., A.P.-L.), Division of Cognitive Neurology, and Parkinson's Disease and Movement Disorders Center (D.K.S., A.P.-L.), Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Department of Neurology (A.W.) and Ahmanson-Lovelace Brain Mapping Center (A.W.), University of California School of Medicine, Los Angeles; Cleveland Clinic (H.F.), Department of Neurology, OH; Toronto Western Research Institute (R.C.), University of Toronto, Ontario, Canada; University of Florida (A.W.S.), Department of Neurology, Gainesville; University of North Dakota School of Medicine (J.-S.L.), Department of Neurology, Grand Forks; and Center for Brain Health (E.P.), NYU School of Medicine, New York, NY.
• Neurology. 2016 Nov 1; 87 (18): 1907-1915.

ObjectiveTo assess whether multifocal, high-frequency repetitive transcranial magnetic stimulation (rTMS) of motor and prefrontal cortex benefits motor and mood symptoms in patients with Parkinson disease (PD).MethodsPatients with PD and depression were enrolled in this multicenter, double-blind, sham-controlled, parallel-group study of real or realistic (electric) sham rTMS. Patients were randomized to 1 of 4 groups: bilateral M1 ( + sham dorsolateral prefrontal cortex [DLPFC]), DLPFC ( + sham M1), M1 + DLPFC, or double sham. The TMS course consisted of 10 daily sessions of 2,000 stimuli for the left DLPFC and 1,000 stimuli for each M1 (50 × 4-second trains of 40 stimuli at 10 Hz). Patients were evaluated at baseline, at 1 week, and at 1, 3, and 6 months after treatment. Primary endpoints were changes in motor function assessed with the Unified Parkinson's Disease Rating Scale-III and in mood with the Hamilton Depression Rating Scale at 1 month.ResultsOf the 160 patients planned for recruitment, 85 were screened, 61 were randomized, and 50 completed all study visits. Real M1 rTMS resulted in greater improvement in motor function than sham at the primary endpoint (p < 0.05). There was no improvement in mood in the DLPFC group compared to the double-sham group, as well as no benefit to combining M1 and DLPFC stimulation for either motor or mood symptoms.ConclusionsIn patients with PD with depression, M1 rTMS is an effective treatment of motor symptoms, while mood benefit after 2 weeks of DLPFC rTMS is not better than sham. Targeting both M1 and DLPFC in each rTMS session showed no evidence of synergistic effects.Clinicaltrialsgov IdentifierNCT01080794.Classification Of EvidenceThis study provides Class I evidence that in patients with PD with depression, M1 rTMS leads to improvement in motor function while DLPFC rTMS does not lead to improvement in depression compared to sham rTMS.© 2016 American Academy of Neurology.

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