• Yoshihiro Noda, Motoaki Nakamura, Takashi Saeki, Misa Inoue, Hideo Iwanari, and Kiyoto Kasai.
• Laboratory of Neuromodulation, Kinko Hospital, Kanagawa Psychiatric Center, Yokohama, Japan; Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
• Neurosci. Res. 2013 Sep 1; 77 (1-2): 70-7.

AbstractThe long-lasting effects of repetitive transcranial magnetic stimulation (rTMS) on electroencephalogram (EEG) activity are not clear. We aimed to investigate the cumulative rTMS effects on EEG and clinical outcomes in patients with major depression. Twenty-five patients with medication-resistant depression underwent 10 daily rTMS sessions over the left dorsolateral prefrontal cortex. We measured resting EEG and spectrum-power before and after the rTMS course. Clinical efficacy was evaluated with the Hamilton's Depression Rating Scale (HAM-D) and Wisconsin Card Sorting Test (WCST). In an ANOVA model, including all prefrontal electrodes, post hoc analyses revealed significant time effects on the theta (F1,24 = 7.89, P = 0.010; +43%), delta (F1,24 = 6.58, P = 0.017; +26%), and alpha (F1,24 = 4.64, P = 0.042; 31%) bands without site specificity. Clinical correlations were observed between F4 alpha power increases and improvements in HAM-D retardation, F3 alpha power increases and improvements of the absolute changes in perseveration and error number on the WCST, and C3 and C4 theta power increases and improvements of the percent change in perseveration and error number on the WCST following rTMS. Consecutive prefrontal rTMS could induce long-lasting EEG potentiations beyond the aftereffects, resulting in improved cognitive and depressive symptoms.Copyright © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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