• Guang-Pu Liu, Bang-Ping Qian, Yong Qiu, Ji-Chen Huang, Mu Qiao, and Bin Wang.
• Department of Spinal Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China; Department of Spinal Surgery, Xuzhou Central Hospital, Xuzhou, China.
• World Neurosurg. 2020 May 1; 137: e618-e625.

ObjectiveThe present study evaluated the severity of syndesmophytes and its correlation with the spinopelvic and clinical outcomes in patients with ankylosing spondylitis (AS).MethodsThe data from 41 consecutive patients with AS who had undergone pedicle subtraction osteotomy surgery at our institution were reviewed. The computed tomography syndesmophyte score (CTSS), a novel method of evaluating the severity of syndesmophytes, was applied to assess the syndesmophytes of the whole, cervical, thoracic, and lumbar spine. The measured spinopelvic parameters included global kyphosis, sagittal vertical axis, lumbar lordosis, pelvic incidence, pelvic tilt, and sacral slope. The Oswestry disability index questionnaire, C-reactive protein, and erythrocyte sedimentation rate were used to evaluate the clinical outcome. The Pearson correlation test was performed to identify correlations between syndesmophyte severity and the spinopelvic and clinical parameters.ResultsThe Pearson correlation analysis demonstrated that the whole CTSS (WCTSS), cervical CTSS, thoracic CTSS, and lumbar CTSS (LCTSS) correlated significantly with each other (P < 0.05). All the CTSSs correlated positively with age, disease duration, and pelvic tilt (P < 0.05). In addition, both sagittal vertical axis and lumbar lordosis were significantly related to the WCTSS, cervical CTSS, and LCTSS (P < 0.05). The Oswestry disability index correlated negatively with the WCTSS (r = -0.312; P < 0.05), thoracic CTSS (r = -0.314; P < 0.05), and LCTSS (r = -0.343; P < 0.05).ConclusionsIn advanced AS, old age and a long disease duration are risk factors for the progression of syndesmophytes. The progression of syndesmophytes might contribute to spinal sagittal malalignment. With serious syndesmophytes, pelvic retroversion seems to be the major compensatory mechanism for spinal sagittal malalignment.Copyright © 2020 Elsevier Inc. All rights reserved.

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