• Salvatore L Cutuli, Laurent Bitker, Eduardo A Osawa, Zachary O'Brien, Emmanuel Canet, Fumitaka Yanase, Paolo Ancona, Anthony Wilson, Luca Lucchetta, Mark Kubicki, Maria Cronhjort, Luca Cioccari, Lea Peck, Helen Young, Glenn M Eastwood, Johan Mårtensson, Neil J Glassford, and Rinaldo Bellomo.
• Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia. sl.cutuli@gmail.com.
• Crit Care Resusc. 2020 Mar 1; 22 (1): 152515-25.

ObjectiveTo study the cardiovascular effect over 30 minutes following the end of fluid bolus therapy (FBT) with 20% albumin in patients after cardiac surgery.DesignProspective observational study.SettingIntensive care unit of a tertiary university-affiliated hospital.ParticipantsTwenty post-cardiac surgery mechanically ventilated patients with a clinical decision to administer FBT.InterventionFBT with a 100 mL bolus of 20% albumin.Main Outcome MeasuresCardiac index (CI) response was defined by a ≥ 15% increase, while mean arterial pressure (MAP) response was defined by a ≥ 10% increase.ResultsThe most common indication for FBT was hypotension (40%). Median duration of infusion was 7 minutes (interquartile range [IQR], 3-9 min). At the end of FBT, five patients (25%) showed a CI response, which increased to almost half in the following 30 minutes and dissipated in one patient. MAP response occurred in 11 patients (55%) and dissipated in five patients (45%) by a median of 6 minutes (IQR, 6-10 min). CI and MAP responses coexisted in four patients (20%). An intrabolus MAP response occurred in 17 patients (85%) but dissipated in 11 patients (65%) within a median of 7 minutes (IQR, 2-11 min). On regression analysis, faster fluid bolus administration predicted MAP increase at the end of the bolus.ConclusionIn post-cardiac surgery patients, CI response to 20% albumin FBT was not congruous with MAP response over 30 minutes. Although hypotension was the main indication for FBT and a MAP response occurred in most of patients, such response was maximal during the bolus, dissipated in a few minutes, and was dissociated from the CI response.

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