• Paul Secombe, Richard Woodman, Sean Chan, David Pilcher, and Frank van Haren.
• Intensive Care Unit, Alice Springs Hospital, Alice Springs, NT, Australia. paul.secombe@nt.gov.au.
• Crit Care Resusc. 2020 Mar 1; 22 (1): 354435-44.

ObjectiveThe apparent survival benefit of being overweight or obese in critically ill patients (the obesity paradox) remains controversial. Our aim is to report on the epidemiology and outcomes of obesity within a large heterogenous critically ill adult population.DesignRetrospective observational cohort study.SettingIntensive care units (ICUs) in Australia and New Zealand.ParticipantsCritically ill patients who had both height and weight recorded between 2010 and 2018.Outcome MeasuresHospital mortality in each of five body mass index (BMI) strata. Subgroups analysed included diagnostic category, gender, age, ventilation status and length of stay.ResultsData were available for 381 855 patients, 68% of whom were overweight or obese. Increasing level of obesity was associated with lower unadjusted hospital mortality: underweight (11.9%), normal weight (7.7%), overweight (6.4%), class I obesity (5.4%), and class II obesity (5.3%). After adjustment, mortality was lowest for patients with class I obesity (adjusted odds ratio, 0.78; 95% CI, 0.74- 0.82). Adverse outcomes with class II obesity were only seen in patients with cardiovascular and cardiac surgery ICU admission diagnoses, where mortality risk rose with progressively higher BMIs.ConclusionWe describe the epidemiology of obesity within a critically ill Australian and New Zealand population and confirm that some level of obesity is associated with lower mortality, both overall and across a range of diagnostic categories and important subgroups. Further research should focus on potential confounders such as nutritional status and the appropriateness of BMI in isolation as an anthropometric measure in critically ill patients.

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