• Yu Zhang, Liang Shang, Pan-Pan Zhang, Luo-Hai Chen, Wei Wang, Cheng Fang, Meng Qiu, Xing-Yu Feng, Lin Zhou, Meng Zhang, Huang-Ying Tan, Xu-Dong Qiu, Hao Wang, Rong Lin, Qin Zhang, Yu-Jie Zeng, Kai-Zhou Jin, Xian-Jun Yu, Lin Shen, Min-Hu Chen, Jie Li, Le-Ping Li, and Jie Chen.
• Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
• Cancer Med. 2019 Sep 1; 8 (11): 5000-5011.

PurposeThis study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems.MethodsA total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems.ResultsClinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno-neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.ConclusionsOur study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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