• Bruno Revol, Ingrid Jullian-Desayes, Sébastien Bailly, Renaud Tamisier, Yves Grillet, Marc Sapène, Marie Joyeux-Faure, Jean-Louis Pépin, and OSFP National French Registry Scientific Council.
• HP2 Laboratory, Inserm Unit 1042, University Grenoble Alpes, Grenoble, France; EFCR Laboratory, Pole Thorax et Vaisseaux, Grenoble Alpes University Hospital, Grenoble, France; Pharmacovigilance Department, Grenoble Alpes University Hospital, Grenoble, France.
• Chest. 2020 Jul 1; 158 (1): 359-364.

BackgroundDiuretics have been reported as effective for reducing OSA severity by preventing fluid retention and reducing rostral fluid shift. The benefit of diuretics might vary depending on the OSA clinical phenotype and comorbidities. To test this hypothesis, we conducted a propensity score-matched cohort analysis of data from the French national sleep apnea registry "Observatoire Sommeil de la Fédération de Pneumologie."Research QuestionWhich phenotypic subtypes of OSA may benefit from diuretics?Study Design And MethodsA propensity score analysis was used to determine the impact of diuretics on OSA severity. Matching (ratio 1:4) was performed by using a 0.1 collider for the propensity score. Severe OSA was defined as an apnea-hypopnea index (AHI) > 30 events/h, and the usefulness of diuretics was assessed by using a logistic regression model.ResultsThe 69,564 OSA patients studied in the OSFP prospective observational cohort had a median age of 56.9 years (interquartile range: 47.4; 65.6), 67% were men, and the median AHI was 28 (14; 43) events/h. Among them, 9,783 (14.1%) were treated with diuretics. Diuretics reduced OSA severity in overweight or moderately obese patients (P = .03) and in patients with hypertension (P < .01), particularly in patients with hypertension with a BMI between 25 and 35 (P < .01). Diuretics had no significant effect on OSA severity in patients with self-reported low physical activity or heart failure.InterpretationDiuretics appear to have a positive impact on OSA severity in overweight or moderately obese patients with hypertension. A prospective study is needed to confirm that diuretics are of interest in combined therapies for hypertensive patients with OSA.Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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