• Daniela Pierscianek, Yahya Ahmadipour, Klaus Kaier, Marvin Darkwah Oppong, Anna Michel, Sied Kebir, Martin Stuschke, Martin Glas, Ulrich Sure, and Ramazan Jabbarli.
• Department of Neurosurgery, University Hospital Essen, Essen, Germany; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany. Electronic address: daniela.pierscianek@uk-essen.de.
• World Neurosurg. 2020 Jun 1; 138: e370-e380.

BackgroundDespite recent improvements in treatment of glioblastoma (GBM), some patients still have a short survival. We sought to develop a new risk score for preoperative assessment of short-term survival (STS) (<6 months) in patients with GBM.MethodsAll adult patients who underwent surgical resection of GBM between 2004 and 2014 were included (N = 379). Demographic and clinical parameters, which were available at admission, were assessed. Variables were evaluated in univariate and multivariate analyses. The score was validated in a separate cohort of patients with GBM who underwent surgical resection between 2015 and 2018.ResultsThe following independent predictors of STS were integrated into a new score: body height (<169 cm, 1 point), arterial hypertension (1 point), age (≤54 years, 0 points; 55-74 years, 1 points; ≥75 years, 2 points), and poor clinical status (Karnofsky performance scale [KPS] score: ≤60%, 2 points; 70%-80%, 1 point; ≥90%, 0 points). The new risk score, SHORT (Small body height, Hypertension, Older age, Reduced KPS score, short-Term survival), ranged from 0 to 6 points and showed good accuracy of risk estimation for STS in GBM (area under the curve: 0.715). STS rates were 9.7%, 23.1%, and 70% in patients with GBM scoring <2 points, 2-4 points, and >4 points (P < 0.0001). The score was successfully validated (area under the curve: 0.770).ConclusionsThis study presents the SHORT score for preoperative assessment of STS risk in patients with GBM. This risk score needs external validation in larger patient cohorts from other institutions. Our score might be a tool to facilitate treatment decisions in patients with GBM before surgery.Copyright © 2020 Elsevier Inc. All rights reserved.

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