• J Bacchetta, B Ranchin, L Dubourg, and P Cochat.
• David Geffen School of Medicine, UCLA, Los Angeles, USA. justine.bacchetta@chu-lyon.fr
• Arch Pediatr. 2010 Dec 1; 17 (12): 1687-95.

AbstractThere is a recent renewed interest in vitamin D metabolism and pathophysiology, due to its recent description as a hormone with a positive impact on global health rather than a strictly bone hormone: vitamin D could be a protective factor against infection, autoimmunity, cardiovascular morbidity, and cancer. By contrast, vitamin D deficiency appears to be increasingly frequent worldwide. We propose a review of these new aspects of vitamin D metabolism, with a focus on vitamin D status in a local pediatric cohort. There is an urgent need for revisiting current guidelines on vitamin D supplementation and for closely monitoring serum vitamin D in children with chronic diseases, i.e., at greater risk of cardiovascular impairment, bone morbidity, infectious disease, and acute inflammation.Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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