• J. Neurol. Neurosurg. Psychiatr. · May 1974

    Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.

    • B P Hilton and K J Zilkha.
    • J. Neurol. Neurosurg. Psychiatr. 1974 May 1; 37 (5): 593-7.

    AbstractPlatelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.

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