• Blood Transfus · Sep 2016

    Comment Review

    How we treat bleeding associated with direct oral anticoagulants.

    • Giuseppe Marano, Stefania Vaglio, Simonetta Pupella, Giancarlo M Liumbruno, and Massimo Franchini.
    • Italian National Blood Centre, National Institute of Health, Rome, Italy.
    • Blood Transfus. 2016 Sep 1; 14 (5): 465-73.

    AbstractDirect oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow better and safer management of the rapid reversal of their anticoagulant effect.

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