• J Maxwell, C Gwardschaladse, G Lombardo, P Petrone, A Policastro, D Karev, K Prabhakaran, A Betancourt, and C P Marini.
• Division of Trauma Surgery, Surgical Critical Care and Acute Care Surgery, Department of Surgery New York Medical College, Joel A. Halpern Trauma Center, Westchester Medical Center University Hospital, 100 Woods Rd Taylor Pavilion E 138, Valhalla, New York, 10595, USA.
• Eur J Trauma Emerg Surg. 2017 Dec 1; 43 (6): 775-782.

BackgroundThis study evaluated the impact of IC on the optimization of nutritional support and the achievement of +NB in patients with TBI.Materials And Methods27 patients (GCS ≤ 8), treated with a 5-day multimodality monitoring and goal-directed therapy protocol, received enteral nutrition on day 1 followed by IC on days 3 and 5 and assessment of NB on day 7. In the first cohort (n = 11), no adjustment in kcal was made. In the second cohort (n = 16), nutrition was targeted to an RQ of 0.83 by day 3. The first cohort was analyzed with respect to NB status; the second cohort was compared to patients with (-) and +NB of the first cohort. Data (mean ± SD) were analyzed with unpaired t test, and Chi square and Fisher exact tests.Results4/11(36 %) patients in the first cohort had +NB. The predicted mortality by TRISS, substrate utilization, and RQ was significantly lower compared to the second cohort. The mortality predicted by the CrasH model did not differ between the two cohorts. A RQ of 0.74 was associated with the preferential use of fat and protein and -NB, whereas a RQ of 0.84 favored utilization of carbohydrates and +NB. All patients whose kcal intake was adjusted based on the RQ on day 3 reached a +NB by day 7.ConclusionAn increase in kcal ≥25 % in patients with a RQ < 0.83 on day 3 improves substrate utilization, decreases protein utilization and optimizes the achievement of +NB by day 7.

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