• Crit Care · Feb 2019

    Editorial Comment

    Designing nutrition-based interventional trials for the future: addressing the known knowns.

    • Danielle E Bear and Zudin A Puthucheary.
    • Department of Nutrition and Dietetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    • Crit Care. 2019 Feb 19; 23 (1): 53.

    AbstractThe consistent decline in critical illness mortality has a significant effect on trial design, whereby either an improbable effect sizes or large number of patients are required.The signal-to-noise ratio is of particular interest for the critically ill. When considering the potential signal, interventions need to match outcomes in regard to biological plausibility. Provision of nutrition is a complex decision with many underappreciated aspects of noise. However, a fundamental interaction is often not accounted for time.Working as a community to evolve trial design will be our challenge for nutrition interventions in the critically ill for the future.

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