• Critical care clinics · Apr 2020

    Review

    The Angiopoietin-Tie2 Pathway in Critical Illness.

    • Kelsey D Sack, John A Kellum, and Samir M Parikh.
    • Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN330C, Boston, MA 02215, USA.
    • Crit Care Clin. 2020 Apr 1; 36 (2): 201-216.

    AbstractLethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts into overt disseminated intravascular coagulation. Disruption of an endothelial signaling axis, the Angiopoietin-Tie2 pathway, may mediate the abrupt transition from microvascular integrity to pathologic disruption. This review summarizes preclinical and clinical results that implicate the Tie2 pathway as a promising target to restore microvascular health in sepsis and ARDS.Copyright © 2019 Elsevier Inc. All rights reserved.

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