• Critical care clinics · Apr 2020

    Review

    Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis.

    • Sarah Sungurlu, Jessica Kuppy, and Robert A Balk.
    • Division of Pulmonary, Critical Care, and Sleep Medicine, Rush Medical College and Rush University Medical Center, 1725 West Harrison Street, Suite 054, Chicago, IL 606012, USA.
    • Crit Care Clin. 2020 Apr 1; 36 (2): 255-265.

    AbstractThe pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.Copyright © 2019 Elsevier Inc. All rights reserved.

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